Macropinocytosis, mTORC1 and cellular growth control
نویسندگان
چکیده
منابع مشابه
E2F1 Regulates Cellular Growth by mTORC1 Signaling
During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1's ability to bind DNA and to regulate gene transcription, demonstrating that a gene induction expression program is required in this process. Unlike E2F1, E2F...
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Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease. In contrast with the picture for growth factor signalling, the means by which nutrient avai...
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mTORC1 (mammalian target of rapamycin complex 1) is activated by nutrients, growth factors and certain hormones. Signalling downstream of mTORC1 promotes protein synthesis by both activating the processes of translation initiation and elongation, in the short term, and the production of new ribosomes, in the longer term. mTORC1 signalling stimulates the translation of the mRNAs encoding the rib...
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Exosomes are approximately 100-nm vesicles that consist of a lipid bilayer of cellular membranes secreted in large quantities from various types of normal and disease-related cells. Endocytosis has been reported as a major pathway for the cellular uptake of exosomes; however, the detailed mechanisms of their cellular uptake are still unknown. Here, we demonstrate the active induction of macropi...
متن کاملNutrients versus growth factors in mTORC1 activation
Growth factors and nutrients regulate the mechanistic target of rapamycin complex 1 (mTORC1) by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease. In contrast to the picture for growth factor signaling, the means by which nutrient availability leads to ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2017
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-017-2710-y